Medical Laboratory Journal

en Association between C-Reactive Protein Test Result and Clinical Characteristics in Patients with COVID-19 علوم آزمایشگاهی Laboratory Sciences Research Article Research Article <div style="text-align: justify;">Background: In coronavirus disease 2019 (COVID-19), elevated serum levels of C-reactive protein (CRP), a marker of systemic inflammation, are commonly observed. We aimed to investigate the associations between CRP test results and clinical characteristics in patients with COVID-19. Method: In this cross-sectional study, data from 399 patients with COVID-19 were collected through a census method. The patients were divided into a CRP-positive group (n=335) and a CRP-negative group (n=64). Demographical data, laboratory findings, clinical characteristics, and history of some underlying diseases were compared between the two groups. All analyses were carried out in SPSS (version 21). Results: The frequency of hypertension was 40.1% among the study population, 42.4 % among CRP-positive patients, and 28.1% among CRP-negative patients. Diabetes and heart disease were the most common comorbidities among the patients. Dyspnea (60.4%), fever (52.7%), fatigue (45.4%), and dry cough (40.1%) were the most commonly observed symptoms. The mean duration of hospitalization was 8.14±6.18 days, and the mean duration of intensive care unit stay was 9.09±9.41 days. Moreover, CRP positivity was significantly associated with hypertension, immunosuppressive therapy, and higher duration of hospitalization (p<0.05). Conclusion: Pre-existing hypertension, diabetes, and heart disease with the coincidence of some clinical symptoms are associated with higher levels of CRP in COVID-19 patients, which results in longer hospitalization.</div> COVID-19 Testing,SARS-CoV-2,C-reactive protein, 20 25 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1321-1&slc_lang=en&sid=1 Maryam Yaseri maryam.yaseri1400@gmail.com 100319475328460032044 100319475328460032044 No Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Seyyedeh Sahereh Mortazavi Khatibani ssahere.mortazavi@gmail.com 100319475328460032045 100319475328460032045 No Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Arvin Naeimi jcbiomedicalr@gmail.com 100319475328460032046 100319475328460032046 No Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Haniyeh Sadat Fayazi fayazihaniyehsadat@gmail.com 100319475328460032047 100319475328460032047 Yes Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran